2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131254
    (S)-O-Desmethyl Venlafaxine N-Oxide
    (S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (S)-O-Desmethyl Venlafaxine N-Oxide
  • HY-W767767
    2-Oxo-3-hydroxy-LSD-d10
    2-Oxo-3-hydroxy-LSD-d10 is the deuterium labeled 2-Oxo-3-hydroxy-LSD (HY-137386). 2-Oxo-3-hydroxy-LSD is a metabolite of Lysergic acid diethylamide.
    2-Oxo-3-hydroxy-LSD-d<sub>10</sub>
  • HY-121432
    Kitol
    Kitol is peptide used for after-sun repair cosmetics. The dominant degradation reaction for vitamin A derivatives is heat-induced formation of kitols, i.e., dimers or higher oligomers. Vitamin A esters are used as a model system to evaluate microcalorimetry as a tool for monitoring the stability of heat-sensitive substances.
    Kitol
  • HY-I0736R
    Isonicotinic acid (Standard)
    Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C.
    Isonicotinic acid (Standard)
  • HY-122423
    Desethylamiodarone
    Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis.
    Desethylamiodarone
  • HY-135404
    Anhydrosimvastatin
    Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase.
    Anhydrosimvastatin
  • HY-N11485
    (25R)-12α-Hydroxyspirost-4-en-3-one
    (25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite produced by the action of Nocardia globerula on Hecogenin (HY-N1422).
    (25R)-12α-Hydroxyspirost-4-en-3-one
  • HY-133772
    Venetoclax N-oxide
    Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM.
    Venetoclax N-oxide
  • HY-135386
    5β-​Dutasteride
    5β-Dutasteride is the S configuration of Dutasteride. 5β-Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    5β-​Dutasteride
  • HY-116462
    ONO-EI-601
    ONO-EI-601 is the major metabolite of human neutrophil elastase inhibitor ONO-5046. ONO-5046 has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
    ONO-EI-601
  • HY-143960S
    Givinostat impurity 1-d10 hydrochloride
    Givinostat impurity 1-d10 (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride.
    Givinostat impurity 1-d<sub>10</sub> hydrochloride
  • HY-W270557S
    Lodoxamide impurity 2-d10
    Lodoxamide impurity 2-d10 is deuterium labeled 2-(Diethylamino)-2-oxoacetic acid.
    Lodoxamide impurity 2-d<sub>10</sub>
  • HY-100052R
    6-Hydroxybentazon (Standard)
    6-Hydroxybentazon (Standard) is the analytical standard of 6-Hydroxybentazon. This product is intended for research and analytical applications. 6-Hydroxybentazon is a phase I metabolite of bentazone, and bentazone is a chemical for use in herbicides.
    6-Hydroxybentazon (Standard)
  • HY-135245
    Ezetimibe hydroxy glucuronide
    Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376).
    Ezetimibe hydroxy glucuronide
  • HY-113327R
    1,3,7-Trimethyluric acid (Standard)
    Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury.
    1,3,7-Trimethyluric acid (Standard)
  • HY-144773
    Loxoprofenol-SRS
    Loxoprofenol-SRS, an active metabolite of Loxoprofen, is a new intravenous NSAID. Loxoprofenol-SRS exhibits significantly stronger anti-inflammatory and analgesic activities.
    Loxoprofenol-SRS
  • HY-101433
    N-Acetylprocainamide hydrochloride
    		99.83%
    N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels.
    N-Acetylprocainamide hydrochloride
  • HY-147333
    Trimipramine N-oxide
    Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety.
    Trimipramine N-oxide
  • HY-136142
    Prasugrel chloride impurity
    Prasugrel chloride impurity is a catp impurity of Prasugrel, exacted from patent US20130345428A1, line 0053. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel chloride impurity
  • HY-144146S
    Pramipexole impurity 7-d10
    Pramipexole impurity 7-d10 is the deuterium labeled Pramipexole impurity 7.
    Pramipexole impurity 7-d<sub>10</sub>
Cat. No. Product Name / Synonyms Application Reactivity